2 edition of Teratogenic Mechanisms (Advances in the Study of Birth Defects) found in the catalog.
Teratogenic Mechanisms (Advances in the Study of Birth Defects)
May 31, 1979
Written in English
|The Physical Object|
|Number of Pages||240|
•Large number of teratogens and adverse developmental outcomes makes it difficult to pinpoint unifying mechanisms. •6 principal teratogenic mechanisms based on associations of major birth defects with medications used by women of reproductive age: 1. Folate antagonism 2. Neural crest cell disruption 3. Endocrine disruption 4. Oxidative. This book describes the principles and mechanism of teratogenesis, including the initiating mechanisms during the subcellular or molecular level and .
James Graves Wilson's six principles of teratology, published in , guide research on teratogenic agents and their effects on developing 's six principles were inspired by Gabriel Madeleine Camille Dareste's five principles of experimental teratology published in Teratology is the study of birth defects, and a teratogen is something that . Fifty years ago, prescription of the sedative thalidomide caused a worldwide epidemic of multiple birth defects. The drug is now used in the treatment of leprosy and multiple myeloma. However, its use is limited due to its potent teratogenic activity. The mechanism by which thalidomide causes limb malformations and other developmental defects is a long Cited by:
Teratology is the study of abnormalities of physiological development. It is often thought of as the study of human congenital abnormalities, but it is broader than that, taking into account other non-birth developmental stages, including puberty; and other organisms, including plants. The volume also deals with teratogenic chemicals in undergraduate chemistry laboratories; the principles and mechanisms of teratogenesis; biochemical determinants of chemical teratogenesis; the relationship between maternal occupational exposure and spontaneous abortion; the legal and ethical aspects of fetal protection policies; and safe Format: Hardcover.
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This book brings together some of the more recent and important research findings related to the mechanisms and pathogenesis of abnormal develop ment. It is not only a documentation of the latest experimental work, but it also points out future. About this book Introduction The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases.
This book describes the principles and mechanism of teratogenesis, including the initiating mechanisms during the subcellular or molecular level and the role of bio-activation in teratogenesis.
Investigations have been done on the relationship between spontaneous abortion in women exposed to organic solvents, antineoplastic agents, and chemicals in plastics.
Teratogenic Effects of Drugs is the hardcover version of a computerized database known as the Teratogen Information System (TERIS), the on-line version of which first appeared in This new edition will continue to serve as a reference for use by clinical and research geneticists, teratologists, obstetricians, and pediatricians.5/5(1).
Teratogenic mechanisms by W. Singleton Published by University Park Press in : The scope of this article is to present the most important teratogenic medications and their mechanism of action comprehensively.
During the last decades, it has become deeply understood that Teratogenic Mechanisms book administered to the mothers during pregnancy might have detrimental effects on the physical development of the fetus. The book also deals with teratogenic chemicals in undergraduate chemistry laboratories; the principles and mechanisms of teratogenesis; biochemical determinants of chemical teratogensis; the relationship between maternal occupational exposure and spontaneous abortion; the legal and ethical aspects of foetal protection policies; and safe.
The potentiation of a teratogenic agent by a second agent not itself teratogenic or presented in subteratogenic doses was seen by Woollam and Millen (a). Thyroxine, given on days 11 and 12 in doses of mg, had no deleterious effect on the survival of young, but it considerably reduced the chances of survival of young also exposed to X.
Effects of teratogens during this period of developmental often times results in an “all or none effect.” That is, the effect of the teratogen, if it is to have any effect, will be so profound as to cause a spontaneous abortion.
Some examples of teratogens known to cause human malformations are listed in the table below (Table ).File Size: KB. The Mechanism of Teratogenesis fall into broad categories based on the etiology of congenital malformations: (a). (b). The etiology of human malformations includes both genetic and environmental factors.
Most developmental defects have complex etiology following from interactions of gene-environment-lifestyle factors. D - Suppression is the only defense mechanism listed in which the client channels conflicting energies into growth-promoting activities.
Mr Johnson is a year-old client you have been seeing for several weeks in therapy. Teratogens Chemicals Which Cause Birth Defects, 2nd Revised Edition is a collection of papers that discusses the practical aspect of teratogens, particularly regarding information on the teratogenic potential of chemicals.
This book describes the principles and mechanism of teratogenesis, including the initiating mechanisms during the Book Edition: 2. Additional Physical Format: Online version: Teratogenic mechanisms.
Lancaster, Eng.: MTP Press, © (OCoLC) Document Type: Book: All Authors / Contributors. Teratogenic Mechanisms L. Dencker (auth.), T. Persaud (eds.) The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases.
RESULTS We identified six teratogenic mechanisms associated with medication use: folate antagonism, neural crest cell disruption, endocrine disruption, oxidative stress, vascular disruption and specific receptor- or enzyme-mediated teratogenesis.
Many medications classified as class X are associated with. Teratogenic effects. Teratogenesis may occur as a direct or indirect effect of the drug; alternatively the drug may act as a co-factor or may sensitize the embryo to the harmful effects of some other substance.
Harmful drugs given before the blastocyst is embedded leads to its destruction and resorption. METHODS We used three methods to identify the teratogenic mechanisms of medications: the MEDLINE and EMBASE databases, two recent books on teratogenic agents and a list of drugs classified as U.S.
Food and Drug Administration class D or X. Mechanisms were included only if they are associated with major structural birth defects and medications that are used relatively Cited by: Teratogenic Mechanisms by T. Persaud,available at Book Depository with free delivery worldwide. This multi-author work deals with the practical aspects of teratogens - chemicals which cause birth defects.
It is designed for use as a unique guide to these chemicals in which one can find all relevant information. The issues covered include: how to obtain information about the teratogenic potential of chemicals; teratogenic chemicals in undergraduate chemistry laboratories; safe.
Title:The Molecular Mechanisms of Thalidomide Teratogenicity and Implications for Modern Medicine VOLUME: 17 ISSUE: 2 Author(s):J.
Knobloch*, D. Jungck and A. Koch Affiliation:Medical Clinic III, Bergmannsheil University Hospital, Bürkle-de-la-Camp-Platz 1, Bochum, Department for Internal Medicine II, Pneumology, Allergology and Respiratory Cited by: 4. Teratogenic mechanisms. Baltimore: University Park Press, © (OCoLC) Online version: Teratogenic mechanisms.
Baltimore: University Park Press, © (OCoLC) Document Type: Book: All Authors / Contributors: T V N Persaud.Teratogens and Their Effects Wendy Chung, M.D. Ph.D. Telephone: e-mail: [email protected] SUMMARY A congenital malformation is an anatomical or structural abnormality present at birth.
Congenital malformations may be caused by genetic factors or environmental insults or a combination of the two that occur during prenatal Size: 2MB.Teratogenic drugs: A teratogen is an agent that can disturb the development of the embryo or fetus.
Teratogens halt the pregnancy or produce a congenital malformation (a birth defect). Classes of teratogens include radiation, maternal infections, chemicals, and drugs. Drugs that are capable of acting as teratogens include.